Brain parenchymal changes during normal aging in domestic cats
نویسندگان
چکیده
منابع مشابه
Cellular and Molecular Changes during Normal Aging
This chapter provides developmental neurobiologists with an overview of cellular and molecular changes that occur in the nervous system during aging, describes the current state of understanding of how aging impacts developmental processes operative in the adult nervous system, and considers how developmental mechanisms may contribute to the pathogenesis of neurodegenerative disorders such as A...
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What is the neuroanatomical basis for the decline in brain function that occurs during normal aging? Previous postmortem studies have blamed it on a reduction in spine density, though results remain controversial and spine dynamics were not assessed. We used chronic in vivo two-photon imaging of dendritic spines and axonal boutons in somatosensory cortex for up to 1 year in thy1 GFP mice to tes...
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PURPOSE To evaluate the effect of normal aging on brain volumes and examine the effects of age and sex on the rates of changes in global and regional brain volumes. METHODS A total of 199 normal subjects (65 females and 134 males, mean age=56.4 ± 9.9 years, age range=38.1-82.9 years) were included in this study. Each subject was scanned twice, at an interval of about 2 years (range=1.5-2.3 ye...
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Objective Cognitive impairment is associated with reductions in brain weight and volume. The factors related to morphometric brain changes in cognitively normal aging remain unknown. We aimed to identify which clinical factors are associated with morphometric brain changes in cognitively normal aging. Methods A cross-sectional study of 414 subjects, ≥50 years old submitted to clinical assessm...
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Aging-related changes in the peripheral immune response are well documented, but less is known about changes of the immune response in the central nervous system. Reactivity of microglia, effectors of the brain innate immunity, is known to increase in the aged brain, but little attention has been hitherto devoted to T cell recruitment. Data in rodents point to a gradual enhancement of T cell ho...
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ژورنال
عنوان ژورنال: Pesquisa Veterinária Brasileira
سال: 2018
ISSN: 1678-5150,0100-736X
DOI: 10.1590/1678-5150-pvb-5397